DOLOP-database of bacterial lipoproteins

نویسندگان

  • M. Madan Babu
  • K. Sankaran
چکیده

UNLABELLED Bacterial lipoproteins and lipid modification are gaining importance owing to their essential nature, roles in pathogenesis and interesting commercial applications. We have created an exclusive knowledge base for bacterial lipoproteins by processing information from 510 entries to provide a list of 199 distinct lipoproteins with relevant links to molecular details. Features include functional classification, predictive algorithm for query sequences, primary sequence analysis and lists of predicted lipoproteins from 43 completed bacterial genomes along with interactive information exchange facility. AVAILABILITY The website called Database Of bacterial LipOProteins (DOLOP) is available at http://www.mrc-lmb.cam.ac.uk/genomes/dolop along with additional information on the biosynthetic pathway, supplementary material and other related figures.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A database of bacterial lipoproteins (DOLOP) with functional assignments to predicted lipoproteins.

Lipid modification of the N-terminal Cys residue (N-acyl-S-diacylglyceryl-Cys) has been found to be an essential, ubiquitous, and unique bacterial posttranslational modification. Such a modification allows anchoring of even highly hydrophilic proteins to the membrane which carry out a variety of functions important for bacteria, including pathogenesis. Hence, being able to identify such protein...

متن کامل

LIPOPREDICT: Bacterial lipoprotein prediction server

Bacterial lipoproteins have many important functions owing to their essential nature and roles in pathogenesis and represent a class of possible vaccine candidates. The prediction of bacterial lipoproteins from sequence is thus an important task for computational vaccinology. A Support Vector Machines (SVM) based module for predicting bacterial lipoproteins, LIPOPREDICT, has been developed. The...

متن کامل

Spirochaetal lipoproteins and pathogenesis.

Anchoring of proteins to membranes by lipid modification is a universal strategy of both prokaryotic and eukaryotic cells. The spirochaetes represent a distinct bacterial phylum that have utilized the lipoprotein design extensively as evidenced by genome-sequencing studies revealing a large number of different paralogous families of lipoprotein genes, encoding 22 potential lipoproteins in Trepo...

متن کامل

Correlation of Serum Lipids and Lipoproteins with Trace Elements in Water Buffalo (Bubalus bubalis)

To evaluate the correlations of the serum concentrations of trace elements with lipids and lipoproteins in water buffalo (Bubalus bubalis), the serum concentrations of cholesterol, triglyceride, total lipids, very low density lipoproteins (VLDL-cholesterol), low density lipoproteins (LDL-cholesterol) and high density lipoproteins (HDL-cholesterol) and their correlations with serum concentration...

متن کامل

The majority of in vitro macrophage activation exhibited by extracts of some immune enhancing botanicals is due to bacterial lipoproteins and lipopolysaccharides.

We have identified potent monocyte/macrophage activating bacterial lipoproteins within commonly used immune enhancing botanicals such as Echinacea, American ginseng and alfalfa sprouts. These bacterial lipoproteins, along with lipopolysaccharides, were substantially more potent than other bacterially derived components when tested in in vitro monocyte/macrophage activation systems. In experimen...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Bioinformatics

دوره 18 4  شماره 

صفحات  -

تاریخ انتشار 2002